Bcl-2 -938 C>A polymorphism was significantly associated with increased cancer risk in Asians under five genetic models (dominant model: OR = 1.19, 95%CI: 1.08–1.31, P = 0.0005; recessive model: OR = 1.83, 95%CI: 1.28–2.62, P = 0.0009; allelic model: OR = 1.28, 95%CI:1.12–1.47, P = 0.0003; homozygote comparison: OR = 1.96, 95%CI: 1.35–2.85, p = 0.006; heterozygote comparison: OR = 1.11, 95%CI: 1.11–1.23, P = 0.04). The gene discussed is BCL2; the disease is cancer.