Twelve studies evaluating Bcl-2 -938 C>A polymorphism in cancer risk28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39 and fourteen studies evaluating the prognostic value of Bcl-2 -938 C>A polymorphism in cancer16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 30, 38 were included in our meta-analysis. This evidence concerns the gene BCL2 and cancer.