Because the 95% CIs of RERI and API did not include 0, and the 95% CI of S did not include 1 (RERI = 2.10, 95% CI:0.18 - 4.03; API = 0.48, 95% CI:0.19 - 0.77; and S = 2.65, 95% CI:1.01 - 6.94, respectively), it can be considered that an additive gene-environment interaction exists between T2DM and CDKN2A/B (rs10757274) affecting the risk of MI. This evidence concerns the gene CDKN2A and type 2 diabetes mellitus.