Further gene-environment interactions for ADTRP (rs6903956), CDKN2A/B (rs10757274), hypertension, dyslipidemia and T2DM were explored by GMDR and ULR methods, and the results from GMDR indicate that a gene-environment interaction is likely to exist between CDKN2A/B (rs10757274) and T2DM affecting the risk of MI. The gene discussed is CDKN2A; the disease is metabolic syndrome.