Genetic studies on Alzheimer's disease (AD) point to risk factor genes encoding proteins with a known function in local trafficking.1 With different approaches, the intracellular transport of a disintegrin and metalloproteinase 10 (ADAM10), the enzyme responsible for the α-secretase cleavage preventing the formation of amyloid β in primary neurons,2, 3 has also been described. Here, ADAM10 is linked to Alzheimer disease.