TRPM2 and memory impairment: First, TRPM2 deficiency protected against CA1 pyramidal neuronal death induced by transient ischemia (Figures 2,4 and 5), which are in agreement with recent reports.27, 28, 29, 30 Second, preventing transient ischemia-induced CA1 pyramidal neuronal death by TRPM2 deficiency offers strong protection of postischemia memory impairments as assessed by novelty environment habituation test and water maze test (Figure 3), supporting a critical role of TRPM2-dependent CA1 pyramidal neuronal death in the development of learning and memory deficits.