While many diseases are so complex that examining multiple biomarkers is better than examining a single protein, in a study evaluating the use of three cardiac biomarkers, cardiac troponin (c Tnl), creatinine kinase isozyme MB (CK-MB) and myoglobin, it was found that use of c Tnl alone in a POC test was sufficient to diagnose chest pain and prevent myocardial infarction [150]. Here, MB is linked to myocardial infarction.