The production of CC and CXC chemokines that associate with inflammation (MIP-1 alpha/CCL3, MIP-1 beta/CCL4, RANTES/CCL5, and GRO-alpha/CXCL1) was constitutively larger in AE patients than in controls; and the elevated chemokine releases were equal in patients with progressive, stable, or cured AE. Here, CCL5 is linked to acrodermatitis enteropathica.