The Reversa (Ldlr−/−ApoB100/100Mttpfl/flMx1Cre+/+) mouse is a non-surgical regression model, based on the Ldlr−/− mouse, in which the hyperlipidemia can be reversed by inducing the conditional knock out of the microsomal triglyceride transfer protein (MTTP) gene (64). Here, MTTP is linked to hyperlipidemia.