Protein misfolding and aggregation results in accumulations of α-synuclein found in Parkinson’s Disease (Lee et al., 2014) as well as accumulations of tau and amyloid-beta polypeptides responsible for the hallmark neuritic plaques and neurofibrillary tangles associated with Alzheimer’s Disease (Bloom, 2014). The gene discussed is MAPT; the disease is early-onset autosomal dominant Alzheimer disease.