PTGS2 and Alzheimer disease: While COX-2 remains a major player in the generation of oxygen radicals and lipid mediators in propagating inflammation in degenerating neocortex and retina, a third COX enzyme cyclooxygenase-3 (COX-3) may play ancillary roles in membrane-based COX signaling, however the role of COX-3 in AD and progressive neocortical and retinal disease is understudied and not well-understood (Cui et al., 2004; Wu and Wan, 2010).