PTGS2 and Alzheimer disease: Cycooxygenase-2 (COX-2; EC 1.14.99.1; 72 kDa) is the inducible, NF-kB-regulated isotype of the PTGSs, and as the rate-limiting enzyme of the arachidonic acid cycle is up-regulated in anatomical regions of AD brain where it potentiates inflammatory neuropathology (Lukiw and Bazan, 1998; Bazan and Lukiw, 2002; Hoozemans et al., 2008; Lukiw et al., 2012a,b; Cudaback et al., 2014).