Blezer and colleagues showed that AT1 receptor inhibition by non-hypotensive dose of losartan reduced cerebral edema and markedly prolonged survival in SHR.28 In addition, the inhibition of AT1 receptors by losartan prevented brain edema following global cerebral ischemia in the cat.29 These results support the conclusions of the present study that Ang II and AT1 receptors might be involved in the formation of brain edema during I/R injuries. The gene discussed is AGTR1; the disease is edema.