The role of the coupled exchanger mechanism (NHE and NCX) in which the NHE drives the accumulation of [Na+]i coupled to the persistent Na‐channels, and the NCX the increase in [Ca2+]i during ischemia is now well established (Tani and Neely 1989; Ju et al. 1996; Garcia‐Dorado et al. 2012), and inhibitors of either the NHE and NCX have been shown to reduce reperfusion injury (Karmazyn 1999; Inserte et al. 2002; Imahashi et al. 2005). Here, TLX2 is linked to ischemia.