Previous studies have shown that CD147 interacts with the integrins α3β1 and α6β1 in HCC cells and activates the downstream FAK-PI3K-Ca2+ and FAK-paxillin pathways, thus contributing to the processes of cell adhesion, proliferation, differentiation, apoptosis, and tumor progression [42, 43]. The gene discussed is PXN; the disease is hepatocellular carcinoma.