CDKN2B-AS1 and cardiovascular disorder: As for cardiovascular diseases, the massive dysregulation of lncRNAs has been observed in ventricular septal defects, which are the most common form of congenital heart disease [108], and the long polyadenylated antisense noncoding RNA in the INK4 locus (ANRIL) is strongly associated with cardiovascular diseases and other pathologies [109].