MALAT1 and cancer: Tripathi and colleagues reported that MALAT-1 expression is low during G1 and G2 cell cycle phases and high during G1/S and mitosis in human normal and cancer cell lines; moreover, silencing of MALAT-1 induces cellular senescence in human lung fibroblasts and provokes G0/G1 or G2/M phase arrest, depending on cell type [122].