Accordingly, we found that in tumor-bearing mice, PSA− ENZR 42D and 42F xenografts significantly increased the frequency of PD-L1+ (42D p=0.0014, 42F p=0.145), PD-L2+ (42D p=0.0004, 42F p=0.0190) and PDL-1/2+ DC (42D p=0.0003, 42F p=0.0189) compared to CRPC or to PSA+ ENZR 49F xenografts (Fig.3A-C). The gene discussed is PDCD1LG2; the disease is neoplasm.