Furthermore, silencing of p65 could not only partially reverse the increased IC50 values of ADR or CDDP but also partially restore the decreased apoptosis-promoting proteins (PTEN, Bax, cleaved caspase-3) and the increased expression of apoptosis-inhibiting proteins (p-Akt, Bcl-2 and pro-caspase-3) in HCC cells induced by Aurora-A overexpression (Figure 8G and H). The gene discussed is AKT1; the disease is hepatocellular carcinoma.