In a multivariate Cox model that included gender, age, Alchohol intake, liver function, AFP, TNM stage, lymph node metastasis, edmondson grade and Aurora-A protein immunostaining, we found that positive Aurora-A protein expression independently indicated poor prognosis for both 5-year RFS (HR: 2.055; 95% CI: 1.735-3.455; P=0.012) and 5-year OS (HR: 1.554; 95% CI: 1.232-2.598; P=0.005) in HCC patients (Supporting Table 4). The gene discussed is AFP; the disease is hepatocellular carcinoma.