First, we determined the effects of Aurora-A expression on the expression of IκBα in the cytoplasmic and nuclear fractions of HCC cells, and showed that silencing of Aurora-A could lead to the increased expression level of nuclear IκBα protein in SMMC-7721 cells and overexpression of Aurora-A could lead to the decreased expression level of nuclear IκBα protein in HepG2 cells (Figure 8A). Here, NFKBIA is linked to hepatocellular carcinoma.