Also, suppression of NF-κB could mimic the effects of silencing of Aurora-A or miR-21 on chemosensitivity of HCC cells by targeting PTEN/Akt signaling, and attenuated Aurora-A-enhanced miR-21 expression, further suggesting that Aurora-A activates NF-κB to promote chemoresistance in HCC cells by targeting miR-21/PTEN/Akt signaling pathway. The gene discussed is AKT1; the disease is hepatocellular carcinoma.