Predicted regulatory element sequences for NANOG, CREB1, CPBP, BEN, PREB-1, SOX10, and POU2F1 (OCT1) POU6F1 and MEIS1 were highly enriched in the promoter regions of the tissue context dependent genes suggesting their possible roles in stem cells proliferation in HER2-regulated breast cancer tissue. The gene discussed is CREB1; the disease is breast cancer.