Supplementary Figure 1A summarizes IC50 values obtained in the panel of cell lines. Although the absolute IC50 values were slightly higher than the ones obtained in 384 well plates (especially for PF-00477736), the MCL cell lines (black bars) were again more sensitive to both drugs as compared to the DLBCL cells included in the validation step (Supplementary Figure 1A and C). Similar results were obtained by treating this panel of cell lines with another Chk1 inhibitor, AZD-7762 (Supplementary Figure 1B and C). The gene discussed is CHEK1; the disease is mantle cell lymphoma.