TNFAIP3 and plasma cell myeloma: C-JUN transcription factor is implicated in several functions including apoptosis induction in various experimental systems such as multiple myeloma [39]; the positive mediator of FAS inducing apoptosis GADD45B, is crucial for activation of pro-apoptotic genes [40]; NFKBIA and TNFAIP3 are both negative regulators of NFKB, anti apoptotic transcription factor inducing pro-survival pathways [41, 42].