Results from immunohistochemistry (IHC) and TUNEL staining shown in Figure 7, B and C indicated a statistically significant decrease in melanoma cell proliferation (Ki67; P < .001), tumor vasculature (CD31; P < .001) and a statistically significant increase in melanoma cell apoptosis (TUNEL; P < .001). The gene discussed is PECAM1; the disease is melanoma.