This result is similar to previous observations that F. tularensis Schu S4 infection reduces AKT1 gene and protein expression, thereby reducing cytokine response and host defenses against infection (45) Another gene that is active in early time points is androgen receptor (AR), a nuclear receptor that is regulated by target lesson revascularization stimulation and interferon-γ in macrophages (46). The gene discussed is AKT1; the disease is infection.