This complex is known to be involved in the transport of antigens from the cytoplasm to the Endoplasmic Reticulum (ER) for association with the major histocompatibility complex (MHC) class I molecules and TAP1 was previously shown to be transcriptionally active after F. tularensis infection of human cells (38–40) and was found to be one of the genes that could best separate tularemia patients from convalescent patients (38). Here, TAP1 is linked to tularemia.