A recent study showed SLC25A37 mRNA upregulation in SF3B1 mutant bone marrow mononuclear cells of three MDS patients with RARS/-T.38 Evidence is thus mounting to suggest that upregulation of the iron importer SLC25A37 and downregulation of iron exporter ABCB7 may be linked to the increased mitochondrial iron accumulation observed in MDS patients with ring sideroblasts.39 Deregulation of these genes could also be consistent with an impaired ability of mitochondrial pathways to use iron that may result in an attempt to increase iron availability. This evidence concerns the gene ABCB7 and myelodysplastic syndrome.