Genes linked to the pathogenesis of RARS and RCMD-RS, such as ALAS2 and ABCB7, were deregulated (ALAS2 upregulated and ABCB7 downregulated) in both comparisons of SF3B1 mutant with wild type and control. Here, ALAS2 is linked to myelodysplastic syndrome with ring sideroblasts.