CD34 and myelodysplastic syndrome: To gain insight into the spectrum of genes that are deregulated or aberrantly spliced in association with SF3B1 mutation in the hematopoietic stem and progenitor cells (HSPC) of MDS patients, we used deep RNA-Seq to compare the transcriptome of bone marrow CD34+ cells from eight MDS patients with SF3B1 mutation (SF3B1 mutants), four MDS patients with no known splicing mutation (wild type) and five healthy controls (control) (Supplementary Table S3).