SF3B1 and myelodysplastic syndrome: In a previous study, RNA-Seq was used to compare the transcriptome of bone marrow mononuclear cells of two MDS patients with SF3B1 mutation to that of one healthy control.11 One hundred and thirty genes showed significant differential expression, 28 of which overlap with the genes differentially expressed between SF3B1 mutant and control in our study of CD34+ cells.