PRPF8 and acute myeloid leukemia: A recent study showed that defects in the splicing factor gene PRPF8 result in missplicing in myeloid malignancies and are associated with the presence of ring sideroblasts in advanced MDS and AML.46 Interestingly, we observed differential exon usage of PRPF8 in SF3B1 mutant cases compared with control in our study, indicating a link between SF3B1 and PRPF8 and the ring sideroblast phenotype.