BRAF and Ewing sarcoma: Two recent, large-scale studies, involving hundreds of cell lines of different tissue types [8, 9] have confirmed well known genetic markers of drug response (e.g. response to BRAF inhibitors in BRAF mutant cell lines) and identified novel associations such as the marked sensitivity of Ewing’s sarcoma cells harboring the EWS-FLI1 gene translocation to poly(ADP-ribose) polymerase (PARP) inhibitors [8].