POLE and cancer: The TNK2P633Afs*3 frameshift mutation may also be recurrent: we observed TNK2P633Afs*3 (chr3:195,595,228-195,595,229 insC; Hg19) in a POLE-mutant serous EC and this variant has been catalogued by others in cancer cell lines and tumors although in those instances it has not been subjected to technical validation (URL: http://www.cbioportal.org/public-portal/).