MKI67 and colon adenocarcinoma: The immunohistochemical stains (cytokeratin AE1/AE3 (CKAE1/AE3)–positive, chromogranin A (CgA)–positive, synaptophysin-positive, antigen Ki-67 (Ki-67) at 60%, with >20 mitoses/10 high-power fields (hpf)) supported the diagnosis of a metastatic, poorly differentiated form of high-grade colon adenocarcinoma (grade G3, pT3pN2bpM1a, Astler-Coller classification D[4], American Joint Committee on Cancer (AJCC) stage IVA[5]) (Figure 1).