Importantly, even after including the MEA ADP assay results in the multivariate model to account for the change in intrinsic platelet reactivity due to the ADP-receptor antagonist treatment, anemia still remained an independent predictor of HTPR (OR = 2.21, 95% CI = 1.39–3.52; p = 0.001). Here, P2RY1 is linked to anemia.