Based on the literature data demonstrating that COX-2 upregulation and increased levels of prostaglandin precursor start within hours [5], [6], [8], [14] and remain for several days after brain trauma [58], in combination with our data from this and previous studies demonstrating differential roles of EP1 and FP receptor modulators, we suggest the potential application and limitations of prospective drugs acting on the prostaglandin receptors in clinical practice for the treatment of TBI and other acute brain injuries. The gene discussed is PTGER1; the disease is brain injury.