Nevertheless, based on our recent data obtained using a model of intracerebral hemorrhage (ICH) [24], the roles of prostaglandin receptors are complex and the outcomes of inhibition or genetic deletion of some of these receptors, such as EP1, may have opposing effects in different neurological conditions, such as ischemic and hemorrhagic strokes [19], [22]–[24]. Here, PTGER1 is linked to hemorrhagic stroke.