CTSB and malaria: The lysosome-equivalent organelle in malaria parasites is known as the food vacuole, and the major food vacuole proteases include cysteine proteases falcipains and aspartic proteases plasmepsins, which have crucial roles in the bulk degradation process inside this organelle, particularly degradation of haemoglobin that provides amino acids during erythrocytic stage development of the parasite [45].