In brain pathologies with neurodegenerative features, such as ALS (amyotrophic lateral sclerosis), MS, and traumatic brain injury, glial GLT-1 and GLAST are the primary determinants responsible for controlling the level of extracellular glutamate in the brain [23], [24], [25]. The gene discussed is SLC1A3; the disease is amyotrophic lateral sclerosis.