PAK6 and colonic neoplasm: Results from the IHC analysis of 147 stage II and III tissues indicated that there was a significant difference between the PAK6-positive and PAK6-negative groups in the number of patients who developed primary colon cancer recurrence after 5-FU-based chemotherapy; more of the patients with PAK6-positive tumors underwent subsequent recurrence than the patients with PAK6-negative tumors (P < 0.001).