PAK6 and colon carcinoma: In multivariate analysis using the clinicopathological variables such as differentiation grade and vessel invasion, the expression of PAK6 was an independent prognostic marker to predict patient outcomes (Table 2); this suggests that PAK6 is of clinical significance in the diagnosis and prognosis of patients with stage II and III colon carcinomas who are treated with 5-FU-based chemotherapy.