ACP5 and neoplasm: Histomorphometric analyses were performed to quantify the number of multinucleated and TRAP-positive osteoclasts on the bone surface; however no significant differences in the average number of osteoclasts normalized to the mineralized tissue area (N.Oc/B.Ar) and perimeter (N.Oc/B.Pm) were observed in the presence of tumor cells from the ctrKD or β1KD group (Figure 5B).