Since CD57 was upregulated on CAR T cells upon their encounter with AC133+ NCH421 GBM-SCs but not with conventional AC133+ CD133-OE-U251 or WT U251 glioma cells, we next wanted to know whether CD57 upregulation on the T cells depends on the differentiation state of the tumor target cells. The gene discussed is PROM1; the disease is neoplasm.