In GBM models, CARs targeting the human epidermal growth factor receptor 2 (HER2) [15], the epidermal growth factor receptor variant III (EGFRvIII) [16], or the IL-13 receptor α2 (IL13Rα2) [17] have been shown to be effective against GBM stem cell (GBM-SC) lines in preclinical in vitro or in vivo models. This evidence concerns the gene ERBB2 and glioblastoma.