For example, Sorafenib, which is the only standard drug used for the treatment of patients with advanced HCC, is an oral multi-kinase inhibitor that blocks multiple growth factor pathways, including those involving VEGFR-1, -2, -3, PDGFR-β, Raf, RET, and FLT-3 [5]. Here, PDGFRB is linked to hepatocellular carcinoma.