TWIST1 and neoplasm: First, because, as mentioned above, miR-10b is a potent metastamiR, second, because miR-10b also negatively regulates the expression of MICB, making tumor cells less susceptible to NKG2D-mediated killing [7, 10] and third, because the miR-520d-5p-mediated downregulation of TWIST1 results in restoration of E-Cadherin, and this consequently results in the inhibition of cell motility and invasiveness.