In vitro and in vivo, the growth inhibition of MTAP-deficient tumors by L-alanosine was partially ascribed to the induction of apoptosis, which was evidenced by increased Annexin-V and TUNEL labeling in myxofibrosarcomas and reported to be mitochondria-dependent in mantle cell lymphomas [24]. This evidence concerns the gene ANXA5 and mantle cell lymphoma.