In addition, the results from these studies are inconsistent, for example Barsotti & Prives [12] reported that FoxM1 downregulation by p53 is dependent on p21 whereas Millour et al [13] did not find p21-dependent repression of FoxM1 by p53, suggesting the need to improve our understanding of the mechanisms regulating FoxM1 expression by p53 in cancers. The gene discussed is TP53; the disease is cancer.