Interestingly, mucocutaneous candidiasis has been seen in association with anti-IL-17 and anti-IL-22 autoantibodies in autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) syndrome (14, 15), caused by a Mendelian deficiency of the autoimmune regulator (AIRE) gene. Here, AIRE is linked to autoimmune polyendocrine syndrome type 1.