In contrast to preeclampsia, maternal plasma TFPI concentration decreases in patients with PTL (Erez et al., 2010) and preterm PROM (Erez et al., 2008) regardless to the presence of intra-amniotic infection/inflammation, as well as in women with fetal demise (Erez et al., 2009), and does not change in mothers with SGA fetuses (Erez et al., 2008). This evidence concerns the gene TFPI and preeclampsia.