Others reported lower median maternal plasma protein Z concentrations in women with preeclampsia or pyelonephritis and higher proportion of protein Z deficiency (defined as protein Z plasma concentration below the 5th percentile) in patients with preeclampsia or fetal demise than in those with a normal pregnancy (Nien et al., 2008). This evidence concerns the gene TMBIM4 and hyperinsulinemic hypoglycemia, familial, 4.