To support the possible role of PEDF as a player in inflammatory burden of RA, we observed that the circulating PEDF levels, evaluated in a cohort of patients with early RA at the time of RA diagnosis, are higher in obese and overweight than in normal-weight subjects and correlated with systemic inflammation (ESR and CRP) (65). This evidence concerns the gene SERPINF1 and rheumatoid arthritis.