Together with zoledronate or BrHPP, interleukin-2 is used for in vitro expansion of this T-cell population, and also added to the therapeutic schemes in different cancers; however, IL-2 is toxic at high doses (those that are commonly effective), leading to vascular leakage, hyperpyrexia, severe hypotension whereas low, and well-tolerated doses are much less effective in vivo (28, 56). This evidence concerns the gene IL2 and cancer.