A subset of CD27+ CD25high Vδ1 T cells expressing FoxP3 were gradually decreased in the PB of systemic lupus erythematosus patients progressing in the pathogenesis of SLE and these regulatory γδ T cells could be generated in vitro when stimulated with anti γδ-TCR in presence of IL-2 and transforming growth factor-beta (TGF-β) (101). The gene discussed is TGFB1; the disease is systemic lupus erythematosus.