TIMD4 and Autoimmunity: While in some cases dual targeting of PS receptors can compound phenotypic outcomes [for example Tim-4 and MFG-E8 (52) develop autoimmunity at an earlier age, or triple knockout of TAM (Tyro3, Axl, and Mer) (35) have a more potent onset of disease than Mer alone), collectively these data suggest, at least in the mouse, that PS receptors are not functionally redundant.