Five members of hnRNPs including hnRNP U-like protein 2, hnRNPK, hnRNPF, hnRNPM, and hnRNPA2/B1 showed increased O-GlcNAcylation in breast cancer tissues (25), while other work by Rambaruth et al. showed that hnRNP H1, hnRNP D-like, hnRNP A2/B1 were hyper-O-GlcNAcylated in breast cancer cells (26). This evidence concerns the gene HNRNPM and breast cancer.