OGT and cancer: Enhanced O-GlcNAcylation level corresponding to increased OGT and decreased OGA expression is commonly observed in various cancers including bone (41), bladder (42), breast (26, 43–45), bile duct (46), colon (47–49), leukemia (50), liver (51), lung (47), ovary (36), pancreas (30), and prostate (52, 53).