However, the use of EETs analogs and sEH inhibitors is limited due to the recent evidences that EETs also promote tumor growth and metastasis (Figure 2; Michaelis et al., 2005; Jiang et al., 2007; Panigrahy et al., 2011, 2012; Bellien and Joannides, 2013). The gene discussed is EPHX2; the disease is neoplasm.