EPHX2 and Hypertension: Moreover, Kujal et al. (2014) have recently shown that renin (Ren)-2 transgenic rats (TGR) after 5/6 renal mass reduction (i.e., a model of chronic kidney disease associated with Ang II-dependent hypertension), exhibit a profound deficiency of intrarenal availability of EETs, that was mitigated by the use of a sEH inhibitor [cis-4-[4-(3-adamantan-1-yl-ureido)cyclohexyloxy]benzoic acid c-(AUCB)].