A genome-wide shift from distal to proximal alternative polyadenylation site (PAS) and accumulation of shortened transcripts were found in the mouse model for OPMD, A17.1, which was generated by expPABPN1 overexpression in muscles, and in cells with reduced PABPN1 expression (de Klerk et al., 2012; Jenal et al., 2012). Here, PABPN1 is linked to oculopharyngeal muscular dystrophy.