Microglia from AD patients express major histocompatibility complex class II (MHCII) molecules, cyclooxygenase 2 (COX2), and cytokines/chemokines such as monocyte chemotactic protein 1 (MCP-1), TNFα, and IL-1β (Akiyama et al., 2000b). This evidence concerns the gene TNF and Alzheimer disease.