Additionally, a combined structural and diffusion MRI study of 22q11DS found an overall global loss of connectivity (6%) in 22q11DS participants compared to controls (Ottet et al., 2013b), and another study of resting state functional connectivity showed deficits in long range connectivity in 22q11DS youth (Schreiner et al., 2014); these findings are consistent with the AD deficits seen in long range association tracts (i.e., ILF, IFO, SLF) that we observed in 22q11DS. Here, FOXK2 is linked to Alzheimer disease.