In experimental rodent models of ALS pathology (one expressing ALS-causing mutations in superoxide dismutase SOD1 and a second engineered to be deficient in the low molecular weight neurofilament- NFL subunit protein) similar findings have also been reported in spinal cord (Lobsiger et al., 2007; Woodruff et al., 2008; Humayun et al., 2009; Takeuchi et al., 2010; Heurich et al., 2011; Lee et al., 2013) and along peripheral nerves (Chiu et al., 2009). This evidence concerns the gene NEFL and amyotrophic lateral sclerosis.