SERPING1 and brain ischemia: Additional studies have shown that exogenous administration of C1-INH was protective in a variety of brain ischemia experimental models (Heimann et al., 1999; Akita et al., 2003; De Simoni et al., 2003, 2004; Storini et al., 2005; Gesuete et al., 2009; Heydenreich et al., 2012).