Studies showing lower MBL levels in CSF of AD patients when compared to controls (Lanzrein et al., 1998), together with more recent evidence that MBL deficiency in humans is associated with AD risk (Sjölander et al., 2013), underscore the need for further studies to better characterize the role of this pathway in AD pathogenesis and progression. Here, MBL2 is linked to hyperinsulinemic hypoglycemia, familial, 4.