Guo et al. (2009), in a proteomic analysis of the CSF of PD patients and controls, found significantly higher CSF levels of apolipoprotein E, autotoxin, and some SOD1 isoforms, and lower levels of complement C4 when compared with controls, while Pigment epithelium-derived factor (PEDF or serpin F1) was not significantly increased, and complement C3 and haptoglobin were similar in PD patients and controls. This evidence concerns the gene SOD1 and Parkinson disease.