IL6 and Parkinson disease: CSF IL-6 levels have been found to be decreased in PD patients with major depression in comparison with patients with major depression without PD in one study (Pålhagen et al., 2010), while another 4 found higher CSF IL-6 in PD patients than in healthy controls (Blum-Degen et al., 1995; Mogi et al., 1996a; Müller et al., 1998; Mogi and Nagatsu, 1999), and in one of them CSF IL-6 was correlated with PD severity (Müller et al., 1998).