Additional studies in zebrafish showed that the clusterin gene, which encodes a secreted glycoprotein that aids in aggregation and contributes to Alzheimer's disease by colocalizing with plaques (Thambisetty et al., 2010), is similar to its human counterpart and is expressed in the diencephalic choroid plexus and myelencephalic choroid plexus (Jiao et al., 2011). The gene discussed is CLU; the disease is early-onset autosomal dominant Alzheimer disease.