Perturbations in CB1R signaling in these brain regions have been linked to psychopathology and emotional dysregulation, which are common among neuropsychiatric disorders, including anxiety, depression, and schizophrenia (Degenhardt et al., 2003; Laviolette and Grace, 2006; Ahmad et al., 2013; Sanchez-Blazquez et al., 2014). Here, CNR1 is linked to major depressive disorder.