Perturbations in CB1R signaling in these brain regions have been linked to psychopathology and emotional dysregulation, which are common among neuropsychiatric disorders, including anxiety, depression, and schizophrenia (Degenhardt et al., 2003; Laviolette and Grace, 2006; Ahmad et al., 2013; Sanchez-Blazquez et al., 2014). This evidence concerns the gene CNR1 and depressive symptom measurement.