The important observations of this study reveal: (i) a higher level of phospho-AKT in the glioma cells from 12 V-Ha-Ras mice compared to the primary astrocytes from wild type mice (Figure 3 inset), and (ii) an RGDS-dependent decrease in the levels of phospho-AKT in these cells following the treatment of SF1126 (Figure 3A and B). The gene discussed is AKT1; the disease is central nervous system cancer.