However, results from various studies using different transgenic mouse models of human glioma (GFAP-12 V-Ha-Ras-transgenic mice or GFAP-EGFRvIII; GFAP-V12Ha-Ras transgenic mice indicate that the expression of astrocyte-specific EGFRvIII (mutated receptor) alone is not sufficient for the gliomagenesis [6-10]. The gene discussed is GFAP; the disease is central nervous system cancer.